The Big Picture Book of Viruses: Orthomyxoviridae

ICTVdB Description:

Taxonomy: Taxonomic structure of the family.
  • Genus Influenzavirus A
  • Genus Influenzavirus B
  • Genus Influenzavirus C
  • Genus "Thogoto-like Viruses"

Host: Virus infects vertebrates.

Genome: Virions contain 7 segments of to 8 segments of linear negative-sense single stranded RNA.

Total genome length is 12000-15000 nt. The largest segment 2300-2500 nt; of second largest 2300-2500 nt; of third 2200-2300 nt; of fourth 1700-1800 nt; of fifth 1500-1600 nt; of sixth 1400-1500 nt; of seventh 1000-1100 nt; of eighth 800-900 nt. Genome sequence has termina repeated sequences; repeated at both ends. Terminal repeats at the 5'-end 12-13 nucleotides long. Nucleotide sequences of 3'-terminus identical; the same in genera of same family; most on RNA (segments), or on all RNA species. Terminal repeats at the 3'-end 9-11 nucleotides long. Encapsidated nucleic acid solely genomic. Each virion contains defective interfering copies (may be present).

Morphology: Virions enveloped; pleomorphic and filamentous forms occur; spherical, or filamentous; 50-120 nm in diameter, or 20 nm in diameter; 200-300(-3000) nm long. Surface projections of envelope distinct; about 500 spikes (projecting 10-14 nm from the surface); dispersed evenly over all the surface (i.e. haemagglutininesterase (HEF)), or dispersed equally over all the surface, but the various types are in clusters (i.e. haemagglutinin (HA) the major glycoprotein is interposed irregularly by clusters of neuraminidase (NA), ratio of HA to NA about 4-5 to 1). Nucleocapsid(s) enclosed within lipoprotein membrane; nucleoproteins of different size classes with loop at each end; arrangement within virion uncertain. Nucleocapsids filamentous; with no clear modal length (of different size classes); 50-130 nm long; 9-15 nm in diameter. Symmetry helical.

(Note: for more information about the taxonomy and structure of this virus family, see the ICTV database below.)

More Information about
Orthomyxoviruses:
Taxonomy: ICTVdB Data Books: Amazon.com
WWW Sites: ATV Sites! Viral Genomes: Entrez
Tutorials: Available! Viral Genes: Genbank
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Medical Research Articles:
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Orthomyxoviridae - Orthomyxoviruses
EM Images Example Virus Name Image Description
Unclassified Images
several influenza viruses from Linda Stannard, of the Department of Medical Microbiology, University of Cape Town
influsphere
several human influenza virus particles from Flu site of the National Center for Infectious Disease, of the CDC.
vsd10a
animal influenza virus From Prof. Stewart McNulty, Veterinary Sciences, Queen's University, Belfast, UK.
human influenza viruses from Linda Stannard, of the Department of Medical Microbiology, University of Cape Town
flu3c
human influenza viruses from Linda Stannard, of the Department of Medical Microbiology, University of Cape Town
flucolo3
human influenza viruses The envelope contains rigid "spikes" of haemagglutinin and neuraminidase which form a characteristic halo of projections around negatively stained virus particles.

From Linda Stannard, of the Department of Medical Microbiology, University of Cape Town

fluhelx2
influenza virus with viral genome & helical ribonucleo-protein from Linda Stannard, of the Department of Medical Microbiology, University of Cape Town
Classified Images

Genus Influenzavirus A

N/A
Influenza A virus

Genus Influenzavirus A

N/A
Influenza B virus

Genus Influenzavirus C

N/A
Influenza C virus

Genus "Thogoto-like viruses"

N/A
Thogoto virus


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