Post-doctoral fellow
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Post Date: Jan 16, 2017
Job Type: Full time
Degree Requirement: Ph.D.
Years Experience: Entry Level
Start Date: Immediately
Salary: $47,500
Location: US - Missouri - St Louis
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The Diamond laboratory investigates mechanisms of pathogenesis of emerging viruses of global concern. Novel interdisciplinary approaches are used to explore the interface between the virus and host with particular interest in understanding cell- and tissue-specific antiviral immune responses, especially in the brain. Genetic screens, systems biology, and immunological methods are applied to define how viruses cause disease in different tissues and how the host limits this process or in some cases, contributes to pathogenesis. The Diamond laboratory tests hypotheses for physiological relevance in newly generated transgenic animal models and conduct detailed analyses at the molecular, cellular, and organism level. In summary, the Diamond laboratory focuses on both the virus and the host to define basic mechanisms of viral pathogenesis, host immunity, and cellular homeostasis, which can be utilized to mitigate disease.

This project studies an interaction between helminth infection, the microbiome, and flavivirus (e.g., Dengue, Zika, and West Nile virus) pathogenesis. To this end, we have exciting preliminary data in mice showing that even small perturbations in the microbiome influence host immunity to flaviviruses, and that pre-existing helminth infection independently (or dependently) can alter flavivirus infection and disease. We are looking for a self-motivated, well-trained individual (e.g. post-doctoral fellow) ideally with experience in cultivating different worm species (and infecting mice) who is interested in studying host responses to viral infections in the context of co-infection with helminths, changes to the microbiome, and effects on the systemic and gastrointestinal immune system responses. Expertise in helminth propagation and infection is a requirement and experience in viral pathogenesis and microbiome analysis also will be prioritized.

Propagation of gastrointestinal helminths
Infection of mice with gastrointestinal helminths

Viral pathogenesis/microbiome analysis preferred but not required

Contact Details
Name: Michael Diamond
Department: Medicine, Washington University
State/Province: Missouri
Country: United States