Postdoctoral Opportunity in Virology and Virus-Host Interactions
Chandran Lab
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Post Date: Jun 02, 2017
Job Type: Full time
Degree Requirement: Ph.D.
Years Experience: 5+
Start Date: 09/01/17
Location: US - New York - Bronx
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Description
The Chandran Lab (www.chandranlab.org) at Albert Einstein College of Medicine in New York City (www.einstein.yu.edu) seeks a highly motivated postdoctoral research fellow with strong interests in virology, viral entry mechanisms, virus-host cell interactions, and/or the discovery and mechanisms of action of antiviral antibodies.

We study how enveloped emerging viruses enter their host cells and initiate infection. Our work is interdisciplinary in nature, involving forward and reverse viral genetics, host genetics, biochemistry, cell biology, structural biology, and immunology. Our research spans the gamut from basic to highly translational with strong biotech collaborations.

Some of our recent accomplishments include:
• Genetic screens to discover the Niemann-Pick C1 (NPC1) protein as an essential and novel type of receptor for Ebola virus (Carette, Nature 2011; Miller, EMBO J 2012)
• Genetic screens to identify cholesterol regulatory pathways as key determinants of hantavirus infection (Kleinfelter, mBio 2015)
• Identification of host determinants of species-specific Ebola infection in bats (Ng, eLife 2015)
• Engineering of “Trojan horse” bispecific antibodies that target cryptic, intracellular viral epitopes to confer broad anti-ebolavirus protection in vivo (Wec, Science 2016)
• Identification of human antibodies that define critical sites of vulnerability in the ebolavirus glycoprotein spike and provide pan-ebolavirus protection in vivo (Wec, Cell, 2017)

Skills
The ideal candidate will possess exceptional skills in molecular biology, protein chemistry, genetics, and/or cell biology. While a background in virology would be advantageous, it is not essential. He/she will be a team player who can work closely with others to manage collaborative projects both within the lab and with our academic and biotech partners. This position is ideal for a mature individual who can provide leadership and creative input as a senior member of the group.

Notes
Candidates should forward the following items directly to Kartik Chandran (kartik.chandran@einstein.yu.edu):

1. Cover letter discussing their research experience and future interests
2. CV
3. Contact information for three references