HSC Biology Research Associate (BS or MS)


Novartis Institutes for BioMedical Research
View Company Profile

<< Go back

Post Date: Jun 21, 2017
Job Type: Full time
Degree Requirement: Bachelors
Years Experience: 1+
Location: US - Massachusetts - Cambridge
Job Reference: 215577BR
APPLY NOW
    Email Job to a Friend
    Save Job to Inbox
    Printer Friendly

Description
The Novartis Institutes for Biomedical Research (NIBR) is recruiting an innovative scientist to work on a team that will be building and developing novel technologies used to develop ex vivo stem cell therapeutics used in the treatment of a range of genetic diseases. The candidate will be involved in developing techniques and processes for the successful translation of this technology into the clinic. This position requires experience with murine or human hematopoietic stem cell (HSC) biology in order to establish in vitro and in vivo models needed for the characterization of product candidates together with experience in evaluating diverse approaches for gene delivery into HSC to examine the regulation of hematopoiesis in transplant models. The ideal candidate will have demonstrated proficiency in molecular virology, cell and in vivo pharmacology to allow for the characterization of CRISPR/Cas9 modified cells including technical expertise for stem cell biology, viral gene transfer, hematopoiesis, and HSC transplantation. This position is based within the Hematology Disease Area of the Chemical Biology and Therapeutics Department but will be highly collaborative with other Novartis groups including the Genomics Institute of Novartis Research Foundation, the Clinical Translational Unit in Novartis Development and others. This position will work on a highly, collaborative, multi-disciplinary project team to develop therapeutics to treat a range of genetic diseases with this novel technology.

Skills
Minimum Requirements
•        MS or equivalent in a scientific discipline such as biology, chemistry or pharmacology with appropriate and relevant years of experience, or BS with appropriate and relevant years of experience in drug discovery or other related laboratory research
•        Experience in a laboratory focused on hematopoietic stem cells
•        Enthusiasm for working in an interdisciplinary, collaborative research environment

Competencies:
•        Ability to work independently in experimental execution and data analysis
•        Ability to perform mouse handling techniques, bleeding, and injection procedures related to HSC research
•        Proficiency in molecular cloning, sequence and protein analyses, and real-time PCR
•        Proficiency in cell culture, transfection and transduction methods and flow cytometry analyses of blood lineages
•        Proficiency in using viral and non-viral based gene transfer methods
•        Experience in ex vivo/in vitro and in vivo systems to study HSC biology
•        Experience in characterization of gene function using murine models
•        Experience in screening, identification, and characterization of small molecules and/or biologics
•        Possess in-depth knowledge of literature methodology, instrumentation and underlying principles of hematopoietic stem cell (HSC) biology

Notes
The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.