PhD Position
Linda Brunotte
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Post Date: Aug 18, 2017
Job Type: Part time
Degree Requirement: Masters
Years Experience: Entry Level
Start Date: November 1017
Salary: TV-L E13, 65%; 36 months
Location: Germany
Job Reference: LB2017
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During infection, influenza A viruses manipulate the host intracellular environment to allow completion of the viral life cycle. Our work focuses on the identification and characterisation of these virus-host interfaces with the goal to develop novel strategies for antiviral interventions. Posttranslational modification (PTM) of viral proteins by phosphorylation as well as sumoylation and ubiquitylation suggests that these cellular processes are highly important for viral replication. Furthermore, emerging evidence suggests, that ubiquitin is majorly involved in the regulation of the activity of the influenza A virus polymerase activity. We apply classical and novel techniques from the fields of virology, biochemistry and immunology to elucidate how viral replication is influenced by PTMs. This includes reverse genetics, diverse reporter assays, qRT-PCR, RNAi-technology, protein-interaction studies, mass spectrometry, cloning and more. We recently established an ex vivo human lung infection model to study respiratory virus infections directly in human lung tissue. Some studies may require animal experiments.

We are seeking a highly motivated PhD candidate with a strong background in influenza virology, cell biology and immunology. The ideal candidate should have solid practical experience in reverse genetics, virus cultivation, culturing of immortalised and primary cell cultures, immunofluorescence analysis and RNAi-technologies. Experimental knowledge in immunology and cloning is mandatory. Animal work might be required. The candidate should be able to develop new ideas, work independently but also integrate into a multicultural and interdisciplinary team. Required computer skills include known office programs and common programs for sequence and structure analysis of RNA, DNA and proteins.

The position (TV-L E13, 65%; 36 months) is vacant from the 15st of November 2017, in the group of Dr. Linda Brunotte at the Institute of Molecular Virology at the Center for Molecular Biology of Inflammation (ZMBE), Westfälische Wilhelms-University of Münster. For further information, please refer to our website:

Contact Details
Name: Dr. Linda Brunotte
Division: University Muenster
Department: Institute for Virology
Address: Von-Esmarch-Str. 56
City: Muenster
Ph: 004925152213