The Chandran Lab (www.chandranlab.org) at Albert Einstein College of Medicine in New York City (www.einstein.yu.edu) seeks a highly motivated postdoctoral research fellow with strong interests in virology, viral entry mechanisms, virus-host cell interactions, and/or the discovery and mechanisms of action of antiviral antibodies.
We study how enveloped emerging viruses enter their host cells and initiate infection. Our work is interdisciplinary in nature, involving forward and reverse viral genetics, host genetics, biochemistry, cell biology, structural biology, and immunology. Our research spans the gamut from basic to highly translational with strong biotech collaborations.
Some of our recent accomplishments include:
• Genetic screens to discover the Niemann-Pick C1 (NPC1) protein as an essential and novel type of receptor for Ebola virus (Carette, Nature 2011; Miller, EMBO J 2012)
• Genetic screens to identify cholesterol regulatory pathways as key determinants of hantavirus infection (Kleinfelter, mBio 2015)
• Identification of host determinants of species-specific Ebola infection in bats (Ng, eLife 2015)
• Engineering of “Trojan horse” bispecific antibodies that target cryptic, intracellular viral epitopes to confer broad anti-ebolavirus protection in vivo (Wec, Science 2016)
• Identification of human antibodies that define critical sites of vulnerability in the ebolavirus glycoprotein spike and provide pan-ebolavirus protection in vivo (Wec, Cell, 2017)