Influenza Virologist
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Post Date: Jun 21, 2017
Job Type: Full time
Degree Requirement: Doctoral Level
Years Experience: Entry Level
Location: US - Georgia - Atlanta
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Job Description:
Battelle is guided by a founding mission. We invest our knowledge, talents and resources, helping our customers achieve their most important goals. We apply scientific rigor and creativity, succeeding where others may fail and we invest in our communities, making the world better for generations to come. All of us share a common purpose: to solve the greatest challenges of today and tomorrow.

Our 22,000 employees work at the forefront of scientific innovation to tackle critical challenges in security, human health, manufacturing, energy and environmental management. Battelle’s work is grounded in the belief that science, technology and a passion for excellence can make industries more competitive and the world a better place.

Technical On-site Professional Services (TOPS) is a part of the Energy, Health and Environment Business and provides laboratory support to the Centers for Disease Control and Prevention. TOPS is seeking a Molecular Virologist to join a team focused on influenza vaccine research and development. The position is located in the Influenza Division (ID) of the National Center for Immunization and Respiratory Diseases (NCIRD), CCID, CDC at the Roybal Campus, Atlanta, Georgia. TOPS is working with HHS/CDC in supporting efforts for pandemic influenza preparedness. Salary will be determined based on education and experience.

The CDC ID provides critical standards for pandemic preparedness to the US State Public Health Laboratories and acts as a World Health Organization (WHO) reference laboratory supporting international influenza surveillance and response networks. Rapid genetic and antigenic characterization of circulating viral strains coupled with vaccine development are essential components to increase pandemic readiness and response. TOPS is supporting CDC in research and development efforts to eliminate data gaps in influenza surveillance by increasing the diagnostic and immunization tools available to clinical providers, public health laboratories and domestic and international partners. Monitoring influenza viruses through the application of molecular technologies and incorporation of laboratory surveillance with classic epidemiology facilitate detection of new epidemic variants and provide complete and accurate information about influenza viruses posing a pandemic threat. The use of viral genomics and surveillance studies will provide candidate viruses for pre-pandemic and pandemic vaccine development to assist decision makers in formulating management strategies needed during an influenza outbreaks, epidemics or pandemic.

The successful candidate will play a critical role in the development of new approaches to generate influenza vaccine candidate viruses in compliance with good laboratory practice (GLP) regulatory requirements. The incumbent will perform virological, genomic, and functional characterization of vaccine viruses from cell culture or eggs. The applicant will be self-motivated and must have strong expertise in viral genomics/sequencing, molecular virology, and/or classical virology. Preference will be given to applicants with experience in reverse genetics of influenza viruses, working with respiratory viruses in Biosafety Level 3 environments, GLP laboratories, and/or the use of laboratory animals (e.g., mice or ferrets).

Conduct influenza genomic sequencing, analyze and interpret the data.
Develop new methods or vectors to improve efficiency of influenza virus rescue by reverse genetics.
Construct and characterize various customized plasmid DNA molecules.
Rescue, propagation and characterization of influenza viruses in compliance with good laboratory practice (GLP) guidelines
Virus purification from cell culture or eggs by sucrose gradient ultracentrifugation
Perform real-time PCR for virus detection and quantification.
Biochemical/biophysical analysis of virus particles and virus antigen quantification.
Develop new methods for virus and vaccine antigen quantification.
Develop new strategies for improving influenza vaccine immunogenicity, stability and antigen yield in eggs.
Conduct vaccine safety evaluations in small animal models.
Meet urgent demands of mitigating emerging influenza viruses with pandemic potential
Maintain organization and proficiency in Biosafety Level 3 laboratory
Prepare study reports for leadership and manuscripts for publication in scientific journals
Communicate progress orally and in writing with technical monitor and other researchers
Assist the technical monitor with preparation of reports, presentations and papers for publication in scientific journals.

BS 5-8 yrs, MS 2-5 years or PhD, MD, DVM or equivalent plus relevant experience in Virology.
Demonstrated expertise with influenza virus sequencing and/or related molecular virology
Experience with influenza reverse genetics and/or reverse genetics of other RNA viruses
Highly motivated person with meticulous working habits, precise record-keeping, and strong organizational skills
The selected candidate will have to obtain and maintain a CDC security clearance

Battelle’s competitive benefits program includes comprehensive medical and dental care, matching 401K, paid time off, flexible spending accounts, disability coverage, and other benefits that help provide financial protection for you and your family.

Battelle provides employment and opportunities for advancement, compensation, training, and growth according to individual merit, without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, marital status, age, genetic information, or disability. Our goal is for each staff member to have the opportunity to grow to the limits of their abilities and to achieve personal and organizational objectives. We will support positive programs for equal treatment of all staff and full utilization of all qualified employees at all levels within Battelle.