The Luftig laboratory at Duke University School of Medicine seeks a highly motivated postdoctoral researcher with a strong background in virology, molecular cell biology, and/or biochemistry to join our research group studying oncogenic viruses.
Our lab focuses on how the human herpesvirus, EBV, co-opts cellular signaling pathways and transcriptional networks to drive activation and uncontrolled proliferation of human B cells. Our work models the earliest steps in viral oncogenesis and aims to understand how the establishment of EBV latency mimics normal B-cell activation and maturation. New projects in the lab also include studies of epithelial carcinogenesis, single cell studies of B-cell infection and live-cell imaging.
We use many different complementary approaches to study the interaction between EBV and the host. We are open to new ideas and creative approaches to tackle the most challenging problems in the field. We have superb shared resources at Duke, including collaborators, that elevate our work by providing technical advice and unique perspectives to approaching biological problems. Our recent accomplishments include:
• Defining the innate tumor suppressor barriers to EBV-mediated B-cell transformation including the DNA damage response (DDR), activated as a consequence of metabolic stress and limiting deoxyribonucleotide pools (Hafez, Oncogenesis 2017; McFadden, PNAS 2016; Luftig, Ann Rev Virol 2014; Nikitin, Cell Host and Microbe, 2010)
• Discovery of a new temporal model for EBV transformation – defining regulation of survival and transcriptional control from initial infection through latency establishment in primary human B cells (Price, eLife 2017; Price PLoS Path 2015, Price, J Virol 2012)
The laboratory provides a robust training environment for postdocs and other trainees. It is of the utmost importance that rigorous scientific inquiry be supported with equally rigorous mentoring. This includes opportunities to present your work both internally and at regional, national, and international meetings; an expectation of training junior lab members as techniques and concepts are mastered; and a strategic plan for career development whether in academia or beyond.
Applicants are invited to send their curriculum vitae, summary of past work, and contact information for three references to Dr. Micah Luftig via the posting on Academic Jobs Online, https://academicjobsonline.org/ajo/jobs/9313). Please contact Micah at firstname.lastname@example.org with any questions.
Duke University is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual’s age, color, disability, genetic information, gender, gender identity, gender expression, national origin, race, religion, sexual orientation, or veteran status.